Michael Schofield (Wentworth Miller) is a desperate man in a desperate situation. His brother, Lincoln Burrows (Dominic Purcell), has been convicted of a sensational murder and subsequently put on death row in the Fox River State Penitentiary. Despite the overwhelming evidence against Lincoln, Michael is convinced of his innocence. With no other options and time running out, Michael holds up a bank to get himself sent down alongside his brother. Not just content to while away the hours until Lincoln's execution, Michael hatches a plan, helped in no small part by his skills as a structural engineer. With the blueprints to the prison in his possession, Michael plots an elaborate escape to break out Lincoln and prove his brother was framed.

The six-disc set includes 22 addictive episodes, audio commentary on selected episodes, three featurettes, and alternate and deleted scenes.